Low Dose Naltrexone (LDN) refers to the dosage of Naltrexone that is usually 5mg or less which is approximately 10% or less of the usual opioid or alcohol treatment dose. These dosages do require a prescription and must be compounded by compounding pharmacy. At this lower dosage, naltrexone exhibits adaptogenic qualities, including anti-inflammatory and analgesic actions, which have not been reported at the normal dosage. Studies have shown that it can be beneficial in many autoimmune disorders such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and for any person with immune system dysfunction.

LDN has a vast history of being an established prescription medication in many other areas of medical treatment. Since many studies have shown such promise with low dose naltrexone therapy, more studies are being conducted to investigate LDN effectiveness in many other autoimmune diseases. LDN is often used in addition to traditional prescription medications that are typical for treating these various conditions.